- Original Article
- Distribution of CD4+CD25+ T cells and graft-versus-host disease in human hematopoietic stem cell transplantation
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Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2008;51(12):1336-1341. Published online December 15, 2008
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Purpose : This study aimed to determine the frequencies of CD4+CD25+ T cells in donor graft and peripheral blood CD4+CD25+ T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD).
Methods : Seventeen children who underwent HSCT were investigated. CD4+CD25+ T cells in samples from donor grafts and recipient peripheral blood were assessed... |
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- Clinical outcomes of hematopoietic stem cell transplantation from
HLA-matched parental donor in childhood acute leukemia
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Eun Young Cha, Moon Hee Lee, Jae Wook Lee, Young Joo Kwon, Dae Hyoung Lee, Young-Shil Park, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2008;51(1):67-72. Published online January 15, 2008
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Purpose : In this study, we retrospectively analyzed the clinical outcomes of patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) grafted from HLA-matched parents.
Methods : Seven children with acute leukemia (4 acute lymphoblastic leukemia, 3 acute myeloid leukemia) in first complete remission received allogeneic HSCT from their respective parents at the St. Marys Hospital between April, 1999 and October,... |
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- The effects of shortened dexamethasone administration on
remission rate and potential complications during remission
induction treatment for pediatric acute lymphoblastic leukemia
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Jae Wook Lee, Kwang Hee Lee, Young Joo Kwon, Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
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Clin Exp Pediatr. 2007;50(12):1217-1224. Published online December 15, 2007
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Purpose : Due to its high potency against leukemic blasts, our institution has opted for the use of dexamethasone during acute lymphoblastic leukemia (ALL) remission induction, but in our most recent treatment protocol, CMCPL-2005, we shortened the length of steroid treatment from 4 to 3 weeks. We compared both the rates of remission induction and significant complications observed during induction... |
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- Short-term Results of Hematopoietic Stem Cell Transplantation
for Children with Myelodysplastic Syndrome
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Jin Lee, Soh Yeon Kim, Bin Cho, Pil Sang Jang, Nak Gyun Chung, Hack Ki Kim
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Clin Exp Pediatr. 2002;45(3):370-375. Published online March 15, 2002
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Purpose : In most cases, myelodysplastic syndrome(MDS) transforms into a more aggressive state or acute myelogenous leukemia; it's prognosis is very poor. It is believed that hematopoietic stem cell transplantation(HSCT) is the only curative treatment of MDS, but available data in children are very sparse. In this report, the short term outcome of HSCT in childhood MDS was analyzed.
Methods :... |
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- One Hundred Cases of HLA-matched Sibling Allogeneic bone Marrow Transplantation in Children : Single Center Study
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Hack Ki Kim, Bin Cho, Nak Gyun Chung, Dae Chul Jeong, Soh Yeon Kim, Hyun Jung Lee, Kyong Su Lee, Kyung Ja Han, Won Il Kim, Il Bong Choi, Chun Choo Kim
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Clin Exp Pediatr. 2000;43(3):402-410. Published online March 15, 2000
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Purpose : We reviewed 100 cases of HLA-matched sibling allogeneic bone marrow transplantation(
allo-BMT) in children and wish to share these results.
Methods : One hundred children had undergone allo-BMT from HLA-identical siblings between Nov.
1983 and May 1998. There were 50 males and 50 females with a median age of 10 years and a
median follow-up of 38 months. Out of 100 cases,... |
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- Case Report
- A Case of Pulmonary Paragonimiasis
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Jin Hee Hong, Sung Soo Jin, Nak Gyun Chung, Joon Sung Lee
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Clin Exp Pediatr. 1999;42(3):430-436. Published online March 15, 1999
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Paragonimiasis is a parasitic disease found in carnivorous animals which is caused by trematodes of the genus Paragonimus. Human infestation occurs by ingestion of raw or not incompletely cooked freshwater crab or crayfish with the metacercaria. Recently, the prevalence of human paragonimiasis has decreased markedly, however, about one hundred clinical cases have been diagnosed annually by antibody test in Korea.... |
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- Original Article
- Treatment of Aplastic Anemia
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Nak Gyun Chung, Kyu Jin Bhang, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
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Clin Exp Pediatr. 1993;36(8):1059-1066. Published online August 15, 1993
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We performed this study to evaluate the therapeutic responses of bone marrow transplantation and immunosuppressive therapy for aplastic anemia in 103 cases(68 severe and 35 moderate). Among them, 15 cases with severe aplastic anemia having HLA-identical sibling donor underwent bone marrow transplantation, and cases (53 severe and 35 moderate cases) without available HLA-identical sibling donor had received immunosuppressive therapy using... |
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- Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
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Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
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Clin Exp Pediatr. 1993;36(8):1067-1072. Published online August 15, 1993
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Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence... |
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